RESUMO No Brasil, o desempenho científico dos pesquisadores é um dos critérios importantes para a tomada de decisões na concessão de bolsas. Neste contexto, este trabalho teve como objetivo avaliar e comparar o perfil de 82 pesquisadores sêniors (nível 1A-D), os quais recebem bolsa de produtividade CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) em Farmacologia, analisando o padrão de citações de seus artigos e o índice h. O número total de documentos, citações (com e sem autocitação) e o índice h (com e sem autocitação) foram extraídos do banco de dados Scopus. Os resultados obtidos indicaram uma diferença nítida entre os pesquisadores de alta categoria (1A e 1B) na maioria dos parâmetros analisados. No entanto, não houve uma diferença notável entre os pesquisadores das categorias 1C e 1D. Os resultados obtidos podem informar a comunidade científica e as agências de fomento sobre o perfil dos bolsistas PQ 1(A-D) em Farmacologia. E podem ajudar a definir novos critérios de diferenciação entre as categorias de bolsas de produtividade, e consequentemente, uma melhor alocação de bolsas.

ABSTRACT In Brazil, scientific performance of researchers is one important criteria for decision-making in grant allocation. In this context, this study aimed to evaluate and compare the profile of 82 seniors' investigators (graded as level 1A-D) which were receiving CNPq (National Council for Scientific and Technological Development) productivity grant in Pharmacology, by analyzing the pattern of citation of their papers and h-index. Total documents, citations (with and without self-citations) and h-index (with and without self-citations) were retrieved from the Scopus database. The results indicated a clear difference among researchers from the higher categories (1A and 1B) in most of the parameters analyzed. However, no noticeable differentiation was found between researchers from grant category 1C and 1D. The results presented here may inform the scientific community and the grant agencies on the profile of PQ 1(A-D) fellows of Pharmacology, and may help to define new differences within CNPq grant categories, and consequently, a better allocation of grants.

Free radicals induce lipid peroxidation, playing an important role in pathological processes. The injury mediated by free radicals can be measured by conjugated dienes, malondialdehyde, 4-hydroxynonenal, and others. However, malondialdehyde has been pointed out as the main product to evaluate lipid peroxidation. Most assays determine malondialdehyde by its reaction with thiobarbituric acid, which can be measured by indirect (spectrometry) and direct methodologies (chromatography). Though there is some controversy among the methodologies, the selective HPLC-based assays provide a more reliable lipid peroxidation measure. This review describes significant aspects about MDA determination, its importance in pathologies and biological samples treatment.